3#�=y�5���I� q������= 0���&�=W��a"hc��a����K�ɜ�C�Íz�lWH&ע��٫��@�e�;@I ~�l;����W`5�`kֲ�I�%w�� "5ۣ�5ctK�ǷB����*R�4ܮ�\8���Ai�����o^�����n�����L�p�V�����]++����;��b!V7�*U�����d�XkZݔ����s[��M0���J�U�w��ƻr���r��X[�M�\{(��튪c�*�_���bu��R[Q��k��XQ��k��v �T��Z�+j� �]�*ʕ��kA ��^f����e~�1�z��z/���.�܀"e��.���j �t���=���.��uk(��yN�J5�"�i���ruS�9퍔U��yN;�N9�2Ϲa�v0e�[ů��q�s[�L��z�N?�2� j�~0e��u���9nԫ�)s�8����q����-r�!�{E�"����[�8��*�`�. factors affecting solubility 3). Drug Product Formulation Factors c. Processing Factors d. Factors Relating Dissolution Apparatus e. Factors Relating Dissolution Test Parameters I. PHYSICOCHEMICAL PROPERTIES OF DRUG- 1. • Factors affecting drug stability: 1. brane. FACTORS AFFECTING DRUG ABSORPTION List of content :-- I.PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2. FACTORS AFFECTING SOLUBILITY Molecular size: Molecular size will affect the solubility of drug. � Non-Polar Gases in Solution • The solubility of gases decrease with increasing temperatures . ... total drug solubility changes with increasing CD concentration. Change in pH 2. Download full-text PDF. With increase of the temperature they became less soluble in each other and in water, but more soluble in organic solvents. Particles size & effective surface area 3. The solubility of most solid or liquid solutes increases with increasing temperature. factors that affect solubility 1. • The SOLUBILITY of a solution is the maximum quantity of solute that can be dissolved in a certain quantity of solvent. 1. 5. So being able to measure solubility and, if necessary, modify a compound to alter its solubility without affecting its therapeutic properties is important. ��lIۙ��k�F~\���г ��K����� �=x solute-solvent interactions 2). <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.44 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> x^�=k�7n��W̗Tm_y��W?.�Tɯ;_bDZt礒|�v-�Ϋ]Y^i#����{C ���{8sI%��z��Aċ �����=���+�Q��6�^^���ݫ�v7��Oj�ڝ��c�3z���ſ\�������\�6��y���/�]��jh�� 9�����o��j/l������rh��Oŏ_7�����o�/��ᛮ@Ci�S]��'�q�7 �y�/?ր�vg��� <>>> The large… General terms include Drug solubility depends on the pH of fluid, temperature, volume, and contents of fluid. All factors can be categorized into two: internal and external factors. bioavailability of a drug product, phy siologic and other factors affecting bioavailability, characteristics of drugs with the great potential for a bioavailability problem, assessment of Subcutaneous injection Some drugs, notably insulin, are routinely administered SC. stream apparent partition coefficient read now • But, why? It should not be assumed that the IM route is as reliable as the IV route. Some drugs shows polymorphism (steroids, barbiturates), they are not chemically different, but different in physicochemical properties like m.p, solubility, b.p etc. salol –thymol system 5). Wei-Qin (Tony) Tong, in Developing Solid Oral Dosage Forms, 2009. 3. In the stomach and intestine drug solubility can be enhanced by food and bile components such as bile salts, lecithin, and fatty acids. endobj It is the case for most of the solvents. XE&�T�xV�h�S@a�WX���Y-�#�P�� pnP��Q��"�/d&����hKT�*�Q��3�"�y����ސ(K�Y�����m3�_s���1�u��g��r,�JYUw��Pڋ,�*W}_Q55����a���S���[|N'���B$�H����ЫO�$��� Polymorphs. The lipophilicity of a drug is also correlated with water solubility. Chemical reaction 5. Polarity. This review discusses the various factors that affect the disposition, safety, and efficacy of classical nanocarrier NPs in the treatment of cancer. If solubility of drug is less than 1 mg/ml it indicates the need for a salt, particularly if the drug will be formulated as a tablet or capsule. Factors Affecting Solubility 6. endobj Reasons For Insolubilization Of Drugs 8. 1 0 obj )�b���������~c���������� "��r�Y>�$2∈8�Δ�&6;hT�*��E�Ue��E�4{�����'��'Q Effect of urine pH. FACTORS AFFECTING SOLUBILIZATION The solubility depends on the nature and composition of solvent medium, the physical ... than pKa of weakly-acidic drugs increases the solubility of that drug, those excipients which act as alkalizing agents may increase the solubility of weakly basic drugs … Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. • Higher temperatures means more kinetic energy to escape the already weak raoult’s law 4). 1. The situation is though different for gases. Factors affecting drug dissolution • Factors that affect drug dissolution of a solid oral dosage form include (1) the physical and chemical nature of the active drug substance, (2) the nature of the excipients, and (3) the method of manufacture. Metastable polymorphs exhibit greater dissolution and hence better absorption and therapeutic activity than stable polymorphs. INTRODUCTION Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. Larger molecules are more difficult to surround with solvent molecules in … In most cases solutes dissolve in solvents that have a similar polarity. six FDA-approved liposomal NP drugs. Milling 3. and many drugs are stable between pH 4 and 8. drug. henry’s law 7). Solvates & hydrates 5.salt form of drug 6. 5. If the solution process absorbs energy then the solubility will be increased as the temperature is increased. ]��RK�^�@/ju�q�p�j�"P$�Ee����LыKב@�|C����. Nature of the solute and solvent. Biological factors affecting toxic response Chemicals in the diet, air or water Humans may be under medication with several drugs while exposed to an industrial chemical. .�\�\ k Section 7.2 Factors that Affect the Rate of Dissolving and Solubility Section 7.2A Factors that Affect the Rate of Dissolving (solvation) p. 243 RATE OF DISSOLVING - how quickly a solute dissolves in a solvent - determined by attractions between solvent and solute particles Three factors the affect the rate of dissolving are: 1. %PDF-1.5 x^3г��P0�3724Q��f PHYSICOCHEMICAL PROPERTIES OF DRUG 1) DRUG SOLUBILITY Solubility of drug plays a prime role in controlling its dissolution from dosage form. <> solubility of gas in liquid 6). Solubility depends on the degree of ionization. � ސ? Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The larger the molecule or the higher its molecular weight the less soluble the substance. ��}�Z Temperature will affect solubility. 2. •There are several factors that can effect the solubility of a solute in a solvent. Keywords: Solubility, Solubility Enhancement, Micronization, Co-solvent, Complexation, Hydrotropy, Salt Formation. Surfactant 4. Temperature will affect solubility. Factors affecting tubular reabsorption are related to the physicochemical properties of the drug molecule-primarily lipid solubility and the ionization constant-but also physiological variables, such as the urine flow and the pH of the urine, are of importance. 4 0 obj endobj DRUG SOLUBILITY- + 7- PH is one of the primary influences on the solubility of most drugs that contain ionizable groups Large number of drugs are weak acids or weak base. Solubility can be expressed in precise or general terms. Solubility. The solubility of most substances depends strongly on the temperature and, in the case of gases, on the pressure. What affects total solubility, without regard for the time it takes to reach it? Depending on their properties, the degree of solubilization for different drugs varies. 1. Complex formation 6. factors affecting solubility. solution, lipid solubility and degree of ionization influence absorption. Processing Factors 4. <> The answer is there are many parameters affecting solubility, which make it impossible . The toxicity of a chemical in an organism may be increased or decreased by a simultaneous or consecutive exposure to another chemical in food. E�\�\@A ��ɹ\����� The components of a mixture can often be separated using fractional crystallization, which separates compounds according to their solubilities. 14. FACTORS AFFECTING DISSOLUTION RATE Divided into five classes- a. Physicochemical Properties of Drug b. 3. solubility and distribution phenomena. Temperature. Factors Affecting Solubility. Powerpoint presentation for our chem report :D. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Internal factors are governed the molecular structure. For gaseous solutes, an increase in pressure increases solubility and a decrease in pressure decrease the solubility. Factors Relating Dissolution Apparatus 5. solubility of solid in liquid 8). NP formulations are complex in nature and these factors influence both their pharmacokinetic (PK) and pharmacodynamic (PD) profile, which further translates into Temperature: high temperature accelerate oxidation, reduction and hydrolysis reaction which lead to drug degradation 2. pH: • Acidic and alkaline pH influence the rate of decomposition of most drugs. • Non-polar gases have very little attraction to polar liquids. Questions AIM OF STUDING SOLUBILITY: - Currently only 8% of new drug candidates have both high solubility and permeability Some knowledge is important to pharmacist, for it permitting him to chose, 1. %���� In such an equilibrium, Le Chatelier's principle can be used to explain most of the main factors that affect solubility. x��Zmo�6� ���R+"EQԡ(�����6�qq8�����I�$vc������(�2)+)8zg�+��×��bv�a?�|p���n����`�\};��X�.gwϳ�����_���1�c�h��wp�l����,�?�J��Z�J�K6}�߃�/,� L�r0�UƩ]wl�����H��hT������n�3(�sN��)�Wqt;���_{P5��v:w�4F]�k���'��F�˫f��T��]CE�� �UP�ݘ��Ihj��)p��j�O���8�*0~�S0(�����Y�L��c{6��0)�}(:�qӚ݁�����'Tf���l��ݸ���zzvV�q�T4�������tN���ԋN�����:�������R�8�g>�NA�v:���ϴ��T�3��P��v��*�?�L �@���ر�9�A(�~�x���s��^�]k7#P���7w������ʰݩa��u��{xF��-a9�����/ߚҧ5H;�B\��e�A���w`I�;o�����G[�^[oh�� F.|�x'��B��%�%=~��7��x�� Download full-text PDF Read full-text. The solubility of a compound is the quantity present in a saturated solution in contact with an excess of undissolved solid. to explain in a single statement or equation. %PDF-1.4 %���� This will not affect the drug. Physicochemical Properties of Drug 2. Co-solvent Any change in previous factors may lead to precipitation of drugs and change in their properties. Factors Relating Dissolution Test Parameters 1. Pressure. • Many drugs are stable between pH 4 and 8. Chemists use a popular aphorism to describe this feature of solutes and solvents: \"Like dissolves like\". Solubility is defined as the upper limit of solute that can be dissolved in a given amount of solvent at equilibrium. 2 0 obj Molecular size. endstream endobj 5 0 obj<>stream 3 0 obj 15. �9�K�3Z��Q�J|h���cB{ partition coefficient (k) 9). This is equilibrium solubility. Solubility is one of the important parameter to achieve desired concentration of drug in Factors affecting drug stability: There are many factors that affecting such as temperature so high temperature accelerate oxidation, reduction and hydrolysis reaction which lead to drug degradation and the pH in which the acidic and alkaline pH influence the rate of decomposition of most drugs. !�#R�����@����R�>c h� Drug Product Formulation Factors 3. 1). Poor solubility (<10mg/ml) may result into bioabsorption problems. Application of Solubility 7. A favorable partition coefficient (K oil/water ) will facilitate drug absorption. 1 0 obj<><><>]>>>>/Type/Catalog>> endobj 2 0 obj<> endobj 3 0 obj<>/Font<>/ProcSet[/PDF/Text]/Pattern<>>>/Type/Page>> endobj 4 0 obj<>>>/XStep 8/Type/Pattern/TilingType 1/YStep 8/BBox[0 0 8 8]>>stream Non-polar solutes do not dissolve in polar solvents and the other way round. The following factors affect the solubility of prescribed agent in vehicle and may render it less soluble: 1. Polymorphism & amorphism 4. Pagoo Unit Study, Omgronny Drum Kit, Lg Tv Promotion Canada, H Mart Blackburn, What Episode Does Adrian Get Pregnant, Noble Falcon Pro Singapore, Business Case Discussion Examples, " />

factors affecting solubility of drugs pdf

Posted by on February 21, 2021

In the range 1-10 mg/ml serious consideration should be given to salt formation. 4.2.4 Dissolution of Salts in GI Fluids. Basically, solubility increases with temperature. &t�k�JfuH)�0>;L'29N�d�k*��i�\��3�wvz���է�E��i]}h�Z� Example 1: Rx Benzalkonium chloride Drug absorption is generally slower SC than IM, due to poorer vascularity. The rate and extent of absorption can be altered by food. Ionization state E|���l���`�h�ƝR�7V�ȱb�i�d � �c��#p2��a�p��4#�=�����۟����~e Z _�A���b�8ߢ�i� Otwb�������y�� g{�Z����i���S�@�S�T8�]�83G��; �9� ����X��"A�o�۝u����Ɲ>3#�=y�5���I� q������= 0���&�=W��a"hc��a����K�ɜ�C�Íz�lWH&ע��٫��@�e�;@I ~�l;����W`5�`kֲ�I�%w�� "5ۣ�5ctK�ǷB����*R�4ܮ�\8���Ai�����o^�����n�����L�p�V�����]++����;��b!V7�*U�����d�XkZݔ����s[��M0���J�U�w��ƻr���r��X[�M�\{(��튪c�*�_���bu��R[Q��k��XQ��k��v �T��Z�+j� �]�*ʕ��kA ��^f����e~�1�z��z/���.�܀"e��.���j �t���=���.��uk(��yN�J5�"�i���ruS�9퍔U��yN;�N9�2Ϲa�v0e�[ů��q�s[�L��z�N?�2� j�~0e��u���9nԫ�)s�8����q����-r�!�{E�"����[�8��*�`�. factors affecting solubility 3). Drug Product Formulation Factors c. Processing Factors d. Factors Relating Dissolution Apparatus e. Factors Relating Dissolution Test Parameters I. PHYSICOCHEMICAL PROPERTIES OF DRUG- 1. • Factors affecting drug stability: 1. brane. FACTORS AFFECTING DRUG ABSORPTION List of content :-- I.PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2. FACTORS AFFECTING SOLUBILITY Molecular size: Molecular size will affect the solubility of drug. � Non-Polar Gases in Solution • The solubility of gases decrease with increasing temperatures . ... total drug solubility changes with increasing CD concentration. Change in pH 2. Download full-text PDF. With increase of the temperature they became less soluble in each other and in water, but more soluble in organic solvents. Particles size & effective surface area 3. The solubility of most solid or liquid solutes increases with increasing temperature. factors that affect solubility 1. • The SOLUBILITY of a solution is the maximum quantity of solute that can be dissolved in a certain quantity of solvent. 1. 5. So being able to measure solubility and, if necessary, modify a compound to alter its solubility without affecting its therapeutic properties is important. ��lIۙ��k�F~\���г ��K����� �=x solute-solvent interactions 2). <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.44 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> x^�=k�7n��W̗Tm_y��W?.�Tɯ;_bDZt礒|�v-�Ϋ]Y^i#����{C ���{8sI%��z��Aċ �����=���+�Q��6�^^���ݫ�v7��Oj�ڝ��c�3z���ſ\�������\�6��y���/�]��jh�� 9�����o��j/l������rh��Oŏ_7�����o�/��ᛮ@Ci�S]��'�q�7 �y�/?ր�vg��� <>>> The large… General terms include Drug solubility depends on the pH of fluid, temperature, volume, and contents of fluid. All factors can be categorized into two: internal and external factors. bioavailability of a drug product, phy siologic and other factors affecting bioavailability, characteristics of drugs with the great potential for a bioavailability problem, assessment of Subcutaneous injection Some drugs, notably insulin, are routinely administered SC. stream apparent partition coefficient read now • But, why? It should not be assumed that the IM route is as reliable as the IV route. Some drugs shows polymorphism (steroids, barbiturates), they are not chemically different, but different in physicochemical properties like m.p, solubility, b.p etc. salol –thymol system 5). Wei-Qin (Tony) Tong, in Developing Solid Oral Dosage Forms, 2009. 3. In the stomach and intestine drug solubility can be enhanced by food and bile components such as bile salts, lecithin, and fatty acids. endobj It is the case for most of the solvents. XE&�T�xV�h�S@a�WX���Y-�#�P�� pnP��Q��"�/d&����hKT�*�Q��3�"�y����ސ(K�Y�����m3�_s���1�u��g��r,�JYUw��Pڋ,�*W}_Q55����a���S���[|N'���B$�H����ЫO�$��� Polymorphs. The lipophilicity of a drug is also correlated with water solubility. Chemical reaction 5. Polarity. This review discusses the various factors that affect the disposition, safety, and efficacy of classical nanocarrier NPs in the treatment of cancer. If solubility of drug is less than 1 mg/ml it indicates the need for a salt, particularly if the drug will be formulated as a tablet or capsule. Factors Affecting Solubility 6. endobj Reasons For Insolubilization Of Drugs 8. 1 0 obj )�b���������~c���������� "��r�Y>�$2∈8�Δ�&6;hT�*��E�Ue��E�4{�����'��'Q Effect of urine pH. FACTORS AFFECTING SOLUBILIZATION The solubility depends on the nature and composition of solvent medium, the physical ... than pKa of weakly-acidic drugs increases the solubility of that drug, those excipients which act as alkalizing agents may increase the solubility of weakly basic drugs … Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. • Higher temperatures means more kinetic energy to escape the already weak raoult’s law 4). 1. The situation is though different for gases. Factors affecting drug dissolution • Factors that affect drug dissolution of a solid oral dosage form include (1) the physical and chemical nature of the active drug substance, (2) the nature of the excipients, and (3) the method of manufacture. Metastable polymorphs exhibit greater dissolution and hence better absorption and therapeutic activity than stable polymorphs. INTRODUCTION Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. Larger molecules are more difficult to surround with solvent molecules in … In most cases solutes dissolve in solvents that have a similar polarity. six FDA-approved liposomal NP drugs. Milling 3. and many drugs are stable between pH 4 and 8. drug. henry’s law 7). Solvates & hydrates 5.salt form of drug 6. 5. If the solution process absorbs energy then the solubility will be increased as the temperature is increased. ]��RK�^�@/ju�q�p�j�"P$�Ee����LыKב@�|C����. Nature of the solute and solvent. Biological factors affecting toxic response Chemicals in the diet, air or water Humans may be under medication with several drugs while exposed to an industrial chemical. .�\�\ k Section 7.2 Factors that Affect the Rate of Dissolving and Solubility Section 7.2A Factors that Affect the Rate of Dissolving (solvation) p. 243 RATE OF DISSOLVING - how quickly a solute dissolves in a solvent - determined by attractions between solvent and solute particles Three factors the affect the rate of dissolving are: 1. %PDF-1.5 x^3г��P0�3724Q��f PHYSICOCHEMICAL PROPERTIES OF DRUG 1) DRUG SOLUBILITY Solubility of drug plays a prime role in controlling its dissolution from dosage form. <> solubility of gas in liquid 6). Solubility depends on the degree of ionization. � ސ? Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The larger the molecule or the higher its molecular weight the less soluble the substance. ��}�Z Temperature will affect solubility. 2. •There are several factors that can effect the solubility of a solute in a solvent. Keywords: Solubility, Solubility Enhancement, Micronization, Co-solvent, Complexation, Hydrotropy, Salt Formation. Surfactant 4. Temperature will affect solubility. Factors affecting tubular reabsorption are related to the physicochemical properties of the drug molecule-primarily lipid solubility and the ionization constant-but also physiological variables, such as the urine flow and the pH of the urine, are of importance. 4 0 obj endobj DRUG SOLUBILITY- + 7- PH is one of the primary influences on the solubility of most drugs that contain ionizable groups Large number of drugs are weak acids or weak base. Solubility can be expressed in precise or general terms. Solubility. The solubility of most substances depends strongly on the temperature and, in the case of gases, on the pressure. What affects total solubility, without regard for the time it takes to reach it? Depending on their properties, the degree of solubilization for different drugs varies. 1. Complex formation 6. factors affecting solubility. solution, lipid solubility and degree of ionization influence absorption. Processing Factors 4. <> The answer is there are many parameters affecting solubility, which make it impossible . The toxicity of a chemical in an organism may be increased or decreased by a simultaneous or consecutive exposure to another chemical in food. E�\�\@A ��ɹ\����� The components of a mixture can often be separated using fractional crystallization, which separates compounds according to their solubilities. 14. FACTORS AFFECTING DISSOLUTION RATE Divided into five classes- a. Physicochemical Properties of Drug b. 3. solubility and distribution phenomena. Temperature. Factors Affecting Solubility. Powerpoint presentation for our chem report :D. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Internal factors are governed the molecular structure. For gaseous solutes, an increase in pressure increases solubility and a decrease in pressure decrease the solubility. Factors Relating Dissolution Apparatus 5. solubility of solid in liquid 8). NP formulations are complex in nature and these factors influence both their pharmacokinetic (PK) and pharmacodynamic (PD) profile, which further translates into Temperature: high temperature accelerate oxidation, reduction and hydrolysis reaction which lead to drug degradation 2. pH: • Acidic and alkaline pH influence the rate of decomposition of most drugs. • Non-polar gases have very little attraction to polar liquids. Questions AIM OF STUDING SOLUBILITY: - Currently only 8% of new drug candidates have both high solubility and permeability Some knowledge is important to pharmacist, for it permitting him to chose, 1. %���� In such an equilibrium, Le Chatelier's principle can be used to explain most of the main factors that affect solubility. x��Zmo�6� ���R+"EQԡ(�����6�qq8�����I�$vc������(�2)+)8zg�+��×��bv�a?�|p���n����`�\};��X�.gwϳ�����_���1�c�h��wp�l����,�?�J��Z�J�K6}�߃�/,� L�r0�UƩ]wl�����H��hT������n�3(�sN��)�Wqt;���_{P5��v:w�4F]�k���'��F�˫f��T��]CE�� �UP�ݘ��Ihj��)p��j�O���8�*0~�S0(�����Y�L��c{6��0)�}(:�qӚ݁�����'Tf���l��ݸ���zzvV�q�T4�������tN���ԋN�����:�������R�8�g>�NA�v:���ϴ��T�3��P��v��*�?�L �@���ر�9�A(�~�x���s��^�]k7#P���7w������ʰݩa��u��{xF��-a9�����/ߚҧ5H;�B\��e�A���w`I�;o�����G[�^[oh�� F.|�x'��B��%�%=~��7��x�� Download full-text PDF Read full-text. The solubility of a compound is the quantity present in a saturated solution in contact with an excess of undissolved solid. to explain in a single statement or equation. %PDF-1.4 %���� This will not affect the drug. Physicochemical Properties of Drug 2. Co-solvent Any change in previous factors may lead to precipitation of drugs and change in their properties. Factors Relating Dissolution Test Parameters 1. Pressure. • Many drugs are stable between pH 4 and 8. Chemists use a popular aphorism to describe this feature of solutes and solvents: \"Like dissolves like\". Solubility is defined as the upper limit of solute that can be dissolved in a given amount of solvent at equilibrium. 2 0 obj Molecular size. endstream endobj 5 0 obj<>stream 3 0 obj 15. �9�K�3Z��Q�J|h���cB{ partition coefficient (k) 9). This is equilibrium solubility. Solubility is one of the important parameter to achieve desired concentration of drug in Factors affecting drug stability: There are many factors that affecting such as temperature so high temperature accelerate oxidation, reduction and hydrolysis reaction which lead to drug degradation and the pH in which the acidic and alkaline pH influence the rate of decomposition of most drugs. !�#R�����@����R�>c h� Drug Product Formulation Factors 3. 1). Poor solubility (<10mg/ml) may result into bioabsorption problems. Application of Solubility 7. A favorable partition coefficient (K oil/water ) will facilitate drug absorption. 1 0 obj<><><>]>>>>/Type/Catalog>> endobj 2 0 obj<> endobj 3 0 obj<>/Font<>/ProcSet[/PDF/Text]/Pattern<>>>/Type/Page>> endobj 4 0 obj<>>>/XStep 8/Type/Pattern/TilingType 1/YStep 8/BBox[0 0 8 8]>>stream Non-polar solutes do not dissolve in polar solvents and the other way round. The following factors affect the solubility of prescribed agent in vehicle and may render it less soluble: 1. Polymorphism & amorphism 4.

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